28
Apr
2008

Effect of a chronic GSM 900MHz exposure on glia in the rat brain

1: Biomed Pharmacother. 2008 Mar 26 [Epub ahead of print]

Ammari M, Brillaud E, Gamez C, Lecomte A, Sakly M, Abdelmelek H, de Seze R.

Unité de Toxicologie Expérimentale, INERIS, Parc technologique ALATA, BP2, 60550 Verneuil-en-Halatte, France; Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, 7021 Zarzouna, Tunisia.

Extension of the mobile phone technology raises concern about the health effects of 900MHz microwaves on the central nervous system (CNS). In this study we measured GFAP expression using immunocytochemistry method, to evaluate glial evolution 10 days after a chronic exposure (5 days a week for 24 weeks) to GSM signal for 45min/day at a brain-averaged specific absorption rate (SAR)=1.5W/kg and for 15min/day at a SAR=6W/kg in the following rat brain areas: prefrontal cortex (PfCx), caudate putamen (Cpu), lateral globus pallidus of striatum (LGP), dentate gyrus of hippocampus (DG) and cerebellum cortex (CCx). In comparison to sham or cage control animals, rats exposed to chronic GSM signal at 6W/kg have increased GFAP stained surface areas in the brain (p<0.05). But the chronic exposure to GSM at 1.5W/kg did not increase GFAP expression. Our results indicated that chronic exposure to GSM 900MHz microwaves (SAR=6W/kg) may induce persistent astroglia activation in the rat brain (sign of a potential gliosis).

PMID: 18424058 [PubMed - as supplied by publisher]

//www.ncbi.nlm.nih.gov/pubmed/18424058?dopt=AbstractPlus



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