24
Feb
2008

Radiofrequency electromagnetic fields (UMTS, 1,950 MHz) induce genotoxic effects in vitro in human fibroblasts but not in lymphocytes

Int Arch Occup Environ Health. 2008 Feb 16; : 18278508

[My paper] Claudia Schwarz, Elisabeth Kratochvil, Alexander Pilger, Niels Kuster, Franz Adlkofer, Hugo Rüdiger

OBJECTIVE: Universal Mobile Telecommunication System (UMTS) was recently introduced as the third generation mobile communication standard in Europe. This was done without any information on biological effects and genotoxic properties of these particular high-frequency electromagnetic fields. This is discomforting, because genotoxic effects of the second generation standard Global System for Mobile Communication have been reported after exposure of human cells in vitro.

METHODS: Human cultured fibroblasts of three different donors and three different short-term human lymphocyte cultures were exposed to 1,950 MHz UMTS below the specific absorption rate (SAR) safety limit of 2 W/kg. The alkaline comet assay and the micronucleus assay were used to ascertain dose and time-dependent genotoxic effects. Five hundred cells per slide were visually evaluated in the comet assay and comet tail factor (CTF) was calculated. In the micronucleus assay 1,000 binucleated cells were evaluated per assay. The origin of the micronuclei was determined by fluorescence labeled anticentromere antibodies. All evaluations were performed under blinded conditions.

RESULTS: UMTS exposure increased the CTF and induced centromere-negative micronuclei (MN) in human cultured fibroblasts in a dose and time-dependent way. Incubation for 24 h at a SAR of 0.05 W/kg generated a statistically significant rise in both CTF and MN (P = 0.02). At a SAR of 0.1 W/kg the CTF was significantly increased after 8 h of incubation (P = 0.02), the number of MN after 12 h (P = 0.02). No UMTS effect was obtained with lymphocytes, either unstimulated or stimulated with Phytohemagglutinin.

CONCLUSION: UMTS exposure may cause genetic alterations in some but not in all human cells in vitro.

[Pubmed] [Scholar] [EndNote] [BibTex] [Doi]

//lib.bioinfo.pl/pmid:18278508
//www.next-up.org/Newsoftheworld/Database_CEM_EMF.php#1

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Wäre UMTS ein Medikament, würde es jetzt vom Markt genommen

Die Ergebnisse der UMTS-Studie haben die wissenschaftliche Qualitätsprüfung. Das bedeutet, die anonyme Kontrolle durch Fachkollegen auf höchstem Niveau ist ...

//www.premiumpresse.de/waere-umts-ein-medikament-wuerde-es-jetzt-vom-markt-genommen-PR398028.html



//omega.twoday.net/search?q=electromagnetic
//www.buergerwelle.de:8080/helma/twoday/bwnews/search?q=UMTS
//omega.twoday.net/search?q=UMTS
//omega.twoday.net/search?q=genotoxic
//omega.twoday.net/search?q=fibroblasts
//omega.twoday.net/search?q=lymphocytes
//omega.twoday.net/search?q=micronuclei
//omega.twoday.net/search?q=Ärztekammer
//www.buergerwelle.de:8080/helma/twoday/bwnews/search?q=Adlkofer
//omega.twoday.net/search?q=Franz+Adlkofer
//www.buergerwelle.de:8080/helma/twoday/bwnews/search?q=Kuster
//omega.twoday.net/search?q=Niels+Kuster
//www.buergerwelle.de:8080/helma/twoday/bwnews/search?q=Rüdiger
//omega.twoday.net/search?q=Hugo+Rüdiger

Cancer in EU at 'epidemic' levels

//www.theparliament.com/EN/News/200801/c1eab98c-a31d-46ce-a38d-cd49d734b961.htm


From Mast Sanity/Mast Network



//omega.twoday.net/search?q=cancer

Strokes among middle-aged women triple - Up to five children a day in the UK are suffering from undiagnosed strokes

Strokes among middle-aged women triple, despite blood pressure medications
//www.msnbc.msn.com/id/23260665/

Strokes in Middle-Aged Women Triple
//www.time.com/time/health/article/0,8599,1714887,00.html

Up to five children a day in the UK are suffering from undiagnosed strokes, new research suggests.
//news.bbc.co.uk/2/hi/health/7482594.stm



//omega.twoday.net/search?q=stroke
//omega.twoday.net/search?q=blood+pressure


From Mast Sanity/Mast Network

Commentary: Second Japanese Interphone Study

Post Date/Time: 18/02/2008 17:09:00

While this study made two improvements, the existing flaws, particularly the short latency time, made it nearly impossible to find a risk. Because the study did find risks, it should result in a world-wide set of public health actions to substantially reduce the absorbed cellphone radiation. For example, the consistent use of a wired headset and not allowing children to use cellphones. The 5.84-fold glioma risk found for > 1,000 hours (2 cases) of use it confirms the Hardell team's findings of a 1.3-fold risk, for < 1,000 hours (355 cases), a 1.8-fold risk for 1,001 to 2,000 hour (26 cases), and a 3.7-fold risk for > 2,000 hours (21 cases). However, this study found a much higher risk than the Hardell study. Suggesting, because the > 1,000 hours was > 1,000 hours at the highest value for mean maxSAR, that higher SAR values create higher risk. Bottom line: in spite of the BBC's headline "Mobiles 'not brain cancer risk'", the risk of brain tumors from cellphone use exists.

Full Column Entry:
//www.powerwatch.org.uk/columns/morgan/20080218_takebayashi_interphone.asp

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Interphone Studies to Date, An Examination of Poor Study Design, Resulting in an Underestimation of the Risk of Brain Tumors

Post Date/Time: 08/01/2008 12:34:00

With five flaws, each independently underestimating the risk of tumors, it is no wonder why the Interphone studies report a large number of results suggesting cellphone use protects the user from having a brain tumor. The Interphone Study has substantial funding from the deep pockets of the cellphone industry. The additional cost to resolve these flaws could have been accomplished if the industry provided more money. In addition if the participating countries had anticipated the potential cost of a pandemic of tumors, the cost effectiveness of contributing substantially more funds, would have been obvious. Lastly, relying on the cellphone industry funding is equivalent to having the fox guard the hen house. The cellphone industry will state that there is a "firewall" between their funds and the research teams who do the study. While it is true that the cellphone industry provides the funds to another organization (UICC) which then decides on the teams that will do each study, the researcher are aware that most of their funds are coming from the cellphone industry. While I do not doubt the integrity of the researchers, I also believe there in an inheren conflict-of-interest best described by the saying, "Don't bite the and that feeds you." The fundamental problem is not conflict-of-interest. The fundamental problem is the Interphone Protocol. While I have no evidence, it would appear that the cellphone industry influenced the Protocol, if not actively participating in its creation. The end result is the Protocol is designed to not find any risk. That it has found a risk is sobering. Tragically, the window of time to do a large, well-designed case-control study is closed. Case-control studies require exposed and unexposed subjects. It is no longer possible to find unexposed subjects.

Full Column Entry:
//www.powerwatch.org.uk/columns/morgan/20080108_interphone_design.asp



//omega.twoday.net/search?q=Interphone
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//omega.twoday.net/search?q=Lloyd+Morgan
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